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KMID : 0613320000060020077
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Journal of the Korean Bone and Joint Tumor Soceity
2000 Volume.6 No. 2 p.77 ~ p.81
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Malignant Peripheral Nerve Sheath Tumor of the Sciatic Nerve in a Patient with Neurofibromatosis
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Song Sang-Ho
Cho Seong-Woo
Shim Chang-Goo
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Abstract
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Malignant peripheral nerve sheath tumors(MPNSTs) are uncommon sarcomas that mostly arise in the soft tissue. They can develop from the pre-existing neurofibromas or schwannomas, or denovo from the peripheral nerves, or they can occur following the radiation therapy. We report a case of MPNST that developed in the sciatic nerve of the patient with neurofibromatosis type-1(NF-1). The patient was a 39-year-old man with the history of NF-1, who’s main symptom was a rapidly enlarging painful mass in his posterior thigh. The well demarcated tumor, 6.5×5×4.5㎝in size, was composed of closely packed spindle cells. Since the patients with NF-1 have a high risk for developing a recurred MPNST, the importance of the clinical follow up is emphasized.
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KEYWORD
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MPNST, Neurofibromatosis, Malignant change
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